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About

Life is full of surprises—

some itchy, some just uncomfortable.

Bug bites won’t wait for your plans, and neither should you. PBZ OTC is crafted for fast, reliable relief from minor itching—so you can get back to living your day without skipping a beat.

PBZ OTC targets the source of the discomfort fast

Scrapes

Provides gentle care for minor cuts and scrapes.

Sunburns

Soothes skin discomfort after a day in the sun.

Minor irritation

Calms skin after contact with plants like poison ivy or oak.

Bug bites

Quick relief from insect bites, wherever you are.

Relief for a new generation

PBZ OTC is powered by Tripelennamine HCl, a powerful antihistamine with a long history of pharmacist trust. Once reserved for prescription use, this established ingredient is now available in a thoughtfully formulated topical cream for today’s families.

PBZ OTC is a versatile solution that provides temporary relief for minor skin irritations—gentle enough for children and effective for adults across all skin types.

Crafted without steroids, PBZ OTC aims to deliver fast, targeted relief while its formulation is designed to help minimize common side effects.

Better relief, fewer risks

PBZ OTC is the first new topical antihistamine in 50 years, offering powerful itch relief in a convenient over‐the‐counter cream. Once available only as a prescription oral tablet, PBZ OTC brings accessible, effective relief for everyday minor skin irritations.

Safe with oral diphenhydramine

Quick relief without side effects

Steroid-free and gentle for daily use

Trusted for toddlers, teens, and adults

How PBZ OTC compares to other creams in the market

PBZ OTC

Benadryl® Cream

Hydrocortisone

PBZ OTC

Benadryl® Cream

Hydrocortisone

Benadryl® is a registered trademark of Johnson & Johnson Consumer Inc. PBZ OTC is not affiliated with or endorsed by Johnson & Johnson Consumer Inc.

“PBZ OTC gave me peace of mind. It’s effective and safe for my son who’s on allergy meds.”

PBZ OTC fits into your daily life

Families

One solution for every itch, from toddlers to teens to grandparents.

Sensitive skin

Gentle enough for delicate or aging skin, powerful enough to stop the discomfort.

Adventurers

Versatile relief for hikes, road trips, and the great outdoors.

Not all itches need medical attention, but some do. Answer a few questions about your symptoms to find out if PBZ OTC is the right choice, or if you should visit a doctor!

Your questions, answered

Yes! PBZ OTC is safe for ages 2 and up, making it the perfect solution for the whole family.

Its active ingredient, Tripelennamine HCl, blocks histamines to stop itching fast.

Unlike steroid-based creams, PBZ OTC is gentle, steroid-free, and safe for regular use. It’s also safe to use with oral allergy medication containing diphenhydramine.

For adults and children 2 years of age and older, we recommend applying PBZ OTC to affected areas no more than 3 to 4 times daily.

No worries—PBZ OTC is safe to use with oral allergy medications, including Benadryl®, ZzzQuil®, and other products containing diphenhydramine.

Feel the PBZ OTC difference

PBZ OTC is now available at Target. Ready to stop itching and get back to life? Try PBZ OTC today and feel the difference for yourself.